What is Sofosvel?
Sofosvel is a fixed dose combination drug used in the treatment of Chronic Hepatitis C (HCV). Sofosbuvir has very high cure rates for all genotypes of HCV infection (HCV genotype 1, 2, 3, 4, 5, or 6). Sofosvel contains sofosbuvir (a HCV nucleotide analog NS5B polymerase inhibitor) and velpatasvir (an HCV NS5A inhibitor).
How is Sofosvel used?
Sofosvel is a combination tablet containing 400mg of Sofosbuvir and 100mg of Velpatasvir. Each pack contains 6 tablets.The most common dosage prescribed is one tablet of Sofosvel daily. This is taken for a 12-week period. In some patients (for example, patients with renal impairment or renal disease) the dosage may need to be adjusted.For treatment of Chronic Hepatitis C (HCV) without cirrhosis or with compensated cirrhosis (Child-Pugh A), Sofosvel is taken alone.For treatment of Chronic Hepatitis C (HCV) with decompensated cirrhosis (Child-Pugh B and C), Sofosvel is taken in combination with ribavirin.
The most common side effects of Sofosvel are headache and tiredness. If taken in combination with ribavirin other common side effects are anemia, nausea, insomnia, and diarrhea.When Sofosvel is used in combination with medicines containing amiodarone it can lead to serious side effects including slowing of the heart rate. This can result in death or need of a pacemaker. If you are taking these medicines in combination, tell your doctor immediately if you notice fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.